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1

Synthesis, Antitumor Activity, and Mechanism of Action of Benzo[ a ]pyrano[3,2- h ]acridin-7-one Analogues of Acronycine

Nguyen, Tuan Minh, Sittisombut, Chavalit, Boutefnouchet, Sabrina, Lallemand, Marie-Christine, Michel, Sylvie, Koch, Michel, Tillequin, François, Mazinghien, Romain, Lansiaux, Amélie, David-Cordonnier,

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 400 KB

english, 2006

2

Alkylation of Guanine in DNA by S23906-1, a Novel Potent Antitumor Compound Derived from the Plant Alkaloid Acronycine †

David-Cordonnier, Marie-Hélène, Laine, William, Lansiaux, Amélie, Kouach, Mostafa, Briand, Gilbert, Pierré, Alain, Hickman, John A., Bailly, Christian

Journal:

Year:

2002

Language:

english

File:

PDF, 269 KB

english, 2002

3

Further Insight into the DNA Recognition Mechanism of Trabectedin from the Differential Affinity of Its Demethylated Analogue Ecteinascidin ET729 for the Triplet DNA Binding Site CGA

Marco, Esther, David-Cordonnier, Marie-Hélène, Bailly, Christian, Cuevas, Carmen, Gago, Federico

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 303 KB

english, 2006

4

Synthesis, Antitumor Activity, and Mechanism of Action of Benzo[ b ]chromeno[6,5- g ][1,8]naphthyridin-7-one Analogs of Acronycine

Tian, Wen, Yougnia, Rodrigue, Depauw, Sabine, Lansiaux, Amélie, David-Cordonnier, Marie-Hélène, Pfeiffer, Bruno, Kraus-Berthier, Laurence, Léonce, Stéphane, Pierré, Alain, Dufat, Hanh, Michel, Sylvie

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.39 MB

english, 2014

5

Influence of the Stereoisomeric Position of the Reactive Acetate Groups of the Benzo[b]Acronycine derivative S23906-1 on Its DNA Alkylation, Helix-Opening, Cytotoxic, and Antitumor Activities

Depauw, S., Gaslonde, T., Leonce, S., Kraus-Berthier, L., Laine, W., Lenglet, G., Chiaroni, A., Pfeiffer, B., Bailly, C., Michel, S., Tillequin, F., Pierre, A., David-Cordonnier, M.-H.

Journal:

Molecular Pharmacology

Year:

2009

Language:

english

File:

PDF, 1.31 MB

english, 2009

6

Stereoselectivity, Sequence Specificity and Mechanism of Action of the Azinomycin Epoxide

Marie-Hélène David-Cordonnier, Maxwell Casely-Hayford, Mostafa Kouach, Gilbert Briand, Laurence H. Patterson, Christian Bailly, Mark Searcey

Journal:

Year:

2006

Language:

english

File:

PDF, 268 KB

english, 2006

7

ChemInform Abstract: Photochemical Electrocyclization of 3-Vinylindoles (VIII) to Pyrido[2,3-a]- (IX), Pyrido[4,3-a]- (X) and Thieno[2,3-a]-carbazoles (XIII): Design, Synthesis, DNA Binding and Antitumor Cell Cytotoxicity.

Thomas Lemster, Ulf Pindur, Gaelle Lenglet, Sabine Depauw, Christelle Dassi, Marie-Helene David-Cordonnier

Journal:

Year:

2009

File:

PDF, 37 KB

2009

8

ChemInform Abstract: Synthesis and Biological Evaluation of Dialkylaminoalkylamino Benzo[c][1,7] and [1,8]Phenanthrolines as Antiproliferative Agents.

Tuba Serbetci, Constance Genes, Sabine Depauw, Soizic Prado, Francois-Hugues Poree, Marie-Paule Hildebrand, Marie-Helene David-Cordonnier, Sylvie Michel, Francois Tillequin

Journal:

Year:

2010

Language:

english

File:

PDF, 22 KB

english, 2010

9

A transesterification reaction is implicated in the covalent binding of benzo[b]acronycine anticancer agents with DNA and glutathion

Marie-Hélène David-Cordonnier, William Laine, Mostafa Kouach, Gilbert Briand, Hervé Vezin, Thomas Gaslonde, Sylvie Michel, Huong Doan Thi Mai, Francois Tillequin, Michel Koch, Stéphane Léonce, Alain P

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 316 KB

english, 2004

10

Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring

Samir Messaoudi, Fabrice Anizon, Paul Peixoto, Marie-Hélène David-Cordonnier, Roy M. Golsteyn, Stéphane Léonce, Bruno Pfeiffer, Michelle Prudhomme

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 385 KB

english, 2006

11

Amino- and glycoconjugates of pyrido[4,3,2-kl]acridine. Synthesis, antitumor activity, and DNA binding

Laurent Bouffier, Brigitte Baldeyrou, Marie-Paule Hildebrand, Amélie Lansiaux, Marie-Hélène David-Cordonnier, Danièle Carrez, Alain Croisy, Olivier Renaudet, Pascal Dumy, Martine Demeunynck

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 1.25 MB

english, 2006

12

Synthesis, cytotoxic activity, and DNA binding properties of antitumor cis-1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine cinnamoyl esters

Quyên Do, Wen Tian, Rodrigue Yougnia, Thomas Gaslonde, Bruno Pfeiffer, Alain Pierré, Stéphane Léonce, Laurence Kraus-Berthier, Marie-Hélène David-Cordonnier, Sabine Depauw, Amélie Lansiaux, Romain Maz

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 421 KB

english, 2009

13

DNA and Non-DNA Targets in the Mechanism of Action of the Antitumor Drug Trabectedin

Marie-Hélène David-Cordonnier, Consuelo Gajate, Osvaldo Olmea, William Laine, Janis de la Iglesia-Vicente, Carlos Perez, Carmen Cuevas, Gabriel Otero, Ignacio Manzanares, Christian Bailly, Faustino Mo

Journal:

Chemistry & Biology

Year:

2005

Language:

english

File:

PDF, 418 KB

english, 2005

14

Design, synthesis and biological evaluation of new oligopyrrole carboxamides linked with tricyclic DNA-intercalators as potential DNA ligands or topoisomerase inhibitors

Marie-Hélène David-Cordonnier, Marie-Paule Hildebrand, Brigitte Baldeyrou, Amelie Lansiaux, Christoph Keuser, Kerstin Benzschawel, Thomas Lemster, Ulf Pindur

Journal:

European Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 1.89 MB

english, 2007

15

Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents

Constance Genès, Gaëlle Lenglet, Sabine Depauw, Raja Nhili, Soizic Prado, Marie-Hélène David-Cordonnier, Sylvie Michel, François Tillequin, François-Hugues Porée

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.53 MB

english, 2011

16

Covalent binding to glutathione of the DNA-alkylating antitumor agent, S23906-1

Marie-Hélène David-Cordonnier, William Laine, Alexandra Joubert, Christelle Tardy, Jean-François Goossens, Mostafa Kouach, Gilbert Briand, Huong Doan Thi Mai, Sylvie Michel, Francois Tillequin, Michel

Journal:

Year:

2003

Language:

english

File:

PDF, 595 KB

english, 2003

17

Photochemical electrocyclisation of 3-vinylindoles to pyrido[2,3-a]-, pyrido[4,3-a]- and thieno[2,3-a]-carbazoles: Design, synthesis, DNA binding and antitumor cell cytotoxicity

Thomas Lemster, Ulf Pindur, Gaelle Lenglet, Sabine Depauw, Christelle Dassi, Marie-Hélène David-Cordonnier

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.97 MB

english, 2009

18

Synthesis and biological evaluation of dialkylaminoalkylamino benzo[c][1,7] and [1,8]phenanthrolines as antiproliferative agents

Tuba Şerbetçi, Constance Genès, Sabine Depauw, Soizic Prado, François-Hugues Porée, Marie-Paule Hildebrand, Marie-Hélène David-Cordonnier, Sylvie Michel, François Tillequin

Journal:

European Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.04 MB

english, 2010

19

Activation of p65 NF-κB protein by p210BCR – ABL in a myeloid cell line (P210BCR – ABL activates p65 NF-κB)

Hamdane, Malika, David-Cordonnier, Marie-Helene, D'Halluin, Jean Claude

Journal:

Year:

1997

Language:

english

File:

PDF, 664 KB

english, 1997

20

c-Myb protein binds to the EP element of the HBV enhancer and regulates transcription in synergy with NF-M

Marie-Hélène David-Cordonnier, Malika Hamdane, Jean-Claude D’Halluin

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1999

Language:

english

File:

PDF, 478 KB

english, 1999

21

DNA Minor Groove Induced Dimerization of Heterocyclic Cations: Compound Structure, Binding Affinity, and Specificity for a TTAA Site

Manoj Munde, Arvind Kumar, Raja Nhili, Sabine Depauw, Marie-Hélène David-Cordonnier, Mohamed A. Ismail, Chad E. Stephens, Abdelbasset A. Farahat, Adalgisa Batista-Parra, David W. Boykin, W. David Wils

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 2.56 MB

english, 2010

22

Determination of the human c-Abl consensus DNA binding site

Marie-Hélène David-Cordonnier, Malika Hamdane, Christian Bailly, Jean-Claude D'Halluin

Journal:

Year:

1998

Language:

english

File:

PDF, 402 KB

english, 1998

23

477 POSTER Sequence-selective inhibition of the DNA binding potencies of Pit-1 and Brn-3 transcription factors by phenyl-furan-benzimidazole DNA ligands

P. Peixoto, S. Depauw, M.P. Hildebrand, D.W. Boykin, W.D. Wilson, M.H. David-Cordonnier

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 59 KB

english, 2008

24

500 POSTER Molecular and cellular consequences of glyceraldehyde-3-phosphate- dehydrogenase (GAPDH) direct interaction with the S23906–1/DNA adduct

G. Lenglet, S. Depauw, D. Mendy, A. Pierré, M.H. David-Cordonnier

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 56 KB

english, 2008

25

1215 Involvement of GAPDH in DNA adduct recognition: implication for a DNA destabilizing compound

G. Lenglet, S. Depauw, H. Drobecq, D. Mendy, M.H. David-Cordonnier

Journal:

European Journal of Cancer Supplements

Year:

2009

Language:

english

File:

PDF, 51 KB

english, 2009

26

249 DNA adduct recognition by proteins: identification, binding specificity and molecular consequences for S23906–1/DNA adduct

G. Lenglet, S. Depauw, H. Drobecq, D. Mendy, M.H. David-Cordonnier

Journal:

European Journal of Cancer Supplements

Year:

2010

Language:

english

File:

PDF, 52 KB

english, 2010

27

Novel Diamidino-Substituted Derivatives of Phenyl Benzothiazolyl and Dibenzothiazolyl Furans and Thiophenes: Synthesis, Antiproliferative and DNA Binding Properties

Racané, Livio, Tralić-Kulenović, Vesna, Kraljević Pavelić, Sandra, Ratkaj, Ivana, Peixoto, Paul, Nhili, Raja, Depauw, Sabine, Hildebrand, Marie-Paule, David-Cordonnier, Marie-Hélène, Pavelić,

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 4.50 MB

english, 2010

28

Design of DNA Minor Groove Binding Diamidines That Recognize GC Base Pair Sequences: A Dimeric-Hinge Interaction Motif

Munde, Manoj, Ismail, Mohamed A., Arafa, Reem, Peixoto, Paul, Collar, Catharine J., Liu, Yang, Hu, Laixing, David-Cordonnier, Marie-Hélène, Lansiaux, Amélie, Bailly, Christian, Boykin, David W., Wilso

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 630 KB

english, 2007

29

Synthesis, Cytotoxic Activity, and Mechanism of Action of Furo[2,3- c ]acridin-6-one and Benzo[ b ]furo[3,2- h ]acridin-6-one Analogues of Psorospermin and Acronycine

Boutefnouchet, Sabrina, Gaboriaud-Kolar, Nicolas, Minh, Nguyen Tuan, Depauw, Sabine, David-Cordonnier, Marie-Hélène, Pfeiffer, Bruno, Léonce, Stéphane, Pierré, Alain, Tillequin, François, Lallem

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 525 KB

english, 2008

30

Water-Mediated Binding of Agents that Target the DNA Minor Groove

Liu, Yang, Kumar, Arvind, Depauw, Sabine, Nhili, Raja, David-Cordonnier, Marie-Hélène, Lee, Michael P., Ismail, Mohamed A., Farahat, Abdelbasset A., Say, Martial, Chackal-Catoen, Sarah, Batista-Parr

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 1.42 MB

english, 2011

31

New anticancer active and selective phenylene-bisbenzothiazoles: Synthesis, antiproliferative evaluation and DNA binding

Racané, Livio, Pavelić, Sandra Kraljević, Nhili, Raja, Depauw, Sabine, Paul-Constant, Charles, Ratkaj, Ivana, David-Cordonnier, Marie-Hélène, Pavelić, Krešimir, Tralić-Kulenović, Vesna, Karminski-Zamo

Journal:

European Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 889 KB

english, 2013

32

Efficiency of Incision of an AP Site within Clustered DNA Damage by the Major Human AP Endonuclease †

David-Cordonnier, Marie-Hélène, Cunniffe, Siobhan M. T., Hickson, Ian D., O'Neill, Peter

Journal:

Year:

2002

Language:

english

File:

PDF, 147 KB

english, 2002

33

Novel Substituted Benzothiophene and Thienothiophene Carboxanilides and Quinolones: Synthesis, Photochemical Synthesis, DNA-Binding Properties, Antitumor Evaluation and 3D-Derived QSAR Analysis

Aleksić, Maja, Bertoša, Branimir, Nhili, Raja, Uzelac, Lidija, Jarak, Ivana, Depauw, Sabine, David-Cordonnier, Marie-Hélène, Kralj, Marijeta, Tomić, Sanja, Karminski-Zamola, Grace

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 3.22 MB

english, 2012

34

Antitumor Activity, X-ray Crystal Structure, and DNA Binding Properties of Thiocoraline A, a Natural Bisintercalating Thiodepsipeptide

Negri, Ana, Marco, Esther, García-Hernández, Verónica, Domingo, Alberto, Llamas-Saiz, Antonio L., Porto-Sandá, Silvia, Riguera, Ricardo, Laine, William, David-Cordonnier, Marie-Hélène, Bailly, Christi

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 551 KB

english, 2007

35

Anilides and quinolones with nitrogen-bearing substituents from benzothiophene and thienothiophene series: Synthesis, photochemical synthesis, cytostatic evaluation, 3D-derived QSAR analysis and DNA-binding properties

Aleksić, Maja, Bertoša, Branimir, Nhili, Raja, Depauw, Sabine, Martin-Kleiner, Irena, David-Cordonnier, Marie-Hélène, Tomić, Sanja, Kralj, Marijeta, Karminski-Zamola, Grace

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.26 MB

english, 2014

36

The Unusual Monomer Recognition of Guanine-Containing Mixed Sequence DNA by a Dithiophene Heterocyclic Diamidine

Munde, Manoj, Kumar, Arvind, Peixoto, Paul, Depauw, Sabine, Ismail, Mohamed A., Farahat, Abdelbasset A., Paul, Ananya, Say, Martial V., David-Cordonnier, Marie-Hélène, Boykin, David W., Wilson, W. Dav

Journal:

Year:

2014

Language:

english

File:

PDF, 2.22 MB

english, 2014

37

Expanding DNA Sequence Recognition with Minor Groove Binders

Munde, Manoj M., Kumar, Arvind, Nhili, Raja, Depauw, Sabine, David-Cordonnier, Marie-Helen, Boykin, David, Wilson, David

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 51 KB

english, 2011

38

Synthesis, antiproliferative activity and DNA binding properties of novel 5-Aminobenzimidazo[1,2-a]quinoline-6-carbonitriles

Perin, Nataša, Nhili, Raja, Ester, Katja, Laine, William, Karminski-Zamola, Grace, Kralj, Marijeta, David-Cordonnier, Marie-Hélène, Hranjec, Marijana

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.15 MB

english, 2014

39

Recognition and Kinetics for Excision of a Base Lesion within Clustered DNA Damage by the Escherichia coli Proteins Fpg and Nth

David-Cordonnier, Marie-Hélène, Laval, Jacques, O'Neill, Peter

Journal:

Year:

2001

Language:

english

File:

PDF, 157 KB

english, 2001

40

Efficiency of Excision of 8-Oxo-guanine within DNA Clustered Damage by XRS5 Nuclear Extracts and Purified Human OGG1 Protein

David-Cordonnier, Marie-Hélène, Boiteux, Serge, O'Neill, Peter

Journal:

Year:

2001

Language:

english

File:

PDF, 113 KB

english, 2001

41

Structure−Activity Relationships and Mechanism of Action of Antitumor Benzo[ b ]pyrano[3,2- h ]acridin-7-one Acronycine Analogues

Thi Mai, Huong Doan, Gaslonde, Thomas, Michel, Sylvie, Tillequin, François, Koch, Michel, Bongui, Jean-Bernard, Elomri, Abdelhakim, Seguin, Elisabeth, Pfeiffer, Bruno, Renard, Pierre, David-Cordonnier

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 222 KB

english, 2003

42

Synthesis, Cytotoxic Activity, and Mechanism of Action of Furo[2,3- c ]acridin-6-one and Benzo[ b ]furo[3,2- h ]acridin-6-one Analogues of Psorospermin and Acronycine

Boutefnouchet, Sabrina, Gaboriaud-Kolar, Nicolas, Minh, Nguyen Tuan, Depauw, Sabine, David-Cordonnier, Marie-Hélène, Pfeiffer, Bruno, Léonce, Stéphane, Pierré, Alain, Tillequin, François, Lallem

Journal:

Journal of Medicinal Chemistry

Year:

2008

File:

PDF, 30 KB

2008

43

The DNA Binding Domain of the Human c-Abl Tyrosine Kinase Preferentially Binds to DNA Sequences Containing an AAC Motif and to Distorted DNA Structures †

David-Cordonnier, Marie-Hélène, Hamdane, Malika, Bailly, Christian, D'Halluin, Jean-Claude

Journal:

Year:

1998

Language:

english

File:

PDF, 279 KB

english, 1998

44

Novel phenyl and pyridyl substituted derivatives of isoindolines: Synthesis, antitumor activity and DNA binding features

Sović, Irena, Kraljević Pavelić, Sandra, Markova-Car, Elitza, Ilić, Nataša, Nhili, Raja, Depauw, Sabine, David-Cordonnier, Marie-Hélène, Karminski-Zamola, Grace

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.52 MB

english, 2014

45

Design, Synthesis, and DNA-Binding of N -Alkyl(anilino)quinazoline Derivatives

Garofalo, Antonio, Goossens, Laurence, Baldeyrou, Brigitte, Lemoine, Amélie, Ravez, Séverine, Six, Perrine, David-Cordonnier, Marie-Hélène, Bonte, Jean-Paul, Depreux, Patrick, Lansiaux, Amélie, G

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.59 MB

english, 2010

46

Biological activity and DNA binding studies of 2-substituted benzimidazo[1,2-a]quinolines bearing different amino side chains

Perin, Nataša, Martin-Kleiner, Irena, Nhili, Raja, Laine, William, David-Cordonnier, Marie-Hélène, Vugrek, Oliver, Karminski-Zamola, Grace, Kralj, Marijeta, Hranjec, Marijana

Journal:

Year:

2013

Language:

english

File:

PDF, 945 KB

english, 2013

47

Structure-Dependent Binding of Arylimidamides to the DNA Minor Groove

Chai, Yun, Munde, Manoj, Kumar, Arvind, Mickelson, Leah, Lin, Sen, Campbell, Nancy H., Banerjee, Moloy, Akay, Senol, Liu, Zongying, Farahat, Abdelbasset A., Nhili, Raja, Depauw, Sabine, David-Cordonni

Journal:

Year:

2014

Language:

english

File:

PDF, 2.02 MB

english, 2014

48

Excision of 8-oxoguanine within clustered damage by the yeast OGG1 protein

David-Cordonnier, M.-H.

Journal:

Nucleic Acids Research

Year:

2001

Language:

english

File:

PDF, 175 KB

english, 2001

49

Clustered DNA Damage, Influence on Damage Excision by XRS5 Nuclear Extracts and Escherichia coli Nth and Fpg Proteins

David-Cordonnier, M.-H.

Journal:

Journal of Biological Chemistry

Year:

2000

Language:

english

File:

PDF, 481 KB

english, 2000

50

Novel Stable Camptothecin Derivatives Replacing the E-Ring Lactone by a Ketone Function Are Potent Inhibitors of Topoisomerase I and Promising Antitumor Drugs

Lansiaux, A., Leonce, S., Kraus-Berthier, L., Bal-Mahieu, C., Mazinghien, R., Didier, S., David-Cordonnier, M.-H., Hautefaye, P., Lavielle, G., Bailly, C., Hickman, J. A., Pierre, A.

Journal:

Molecular Pharmacology

Year:

2007

Language:

english

File:

PDF, 657 KB

english, 2007

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